The patient appears to have post- operative low output syndrome. Her heart is no longer responding to volume re- placement and she may now be on the descending limb of the Starling curve. It is vital to aggressively treat this patient and to follow the results of therapy as it progresses. You should be at the bedside looking at the data as well as examining the patient frequently for signs of adequate peripheral perfusion. Such findings as pedal pulses, temperature, color, venous refill and capillary refill are as important as the calculated SVR. The patient needs sequential treatment. Start with an inotrope which does not cause peripheral vasoconstriction such as dobutamine and give an amount known to raise cardiac index (10-15 mcg/kg/ min). Then add dopamine in a renal dosage (5 mcg/kg/min) to increase urine output. Lidocaine should be used to keep the PVC's under 3/min. Furosemide should be used only in small doses to maintain urine output above 30 cc/hr. Too much may make the patient hypovolemic. As these medications are titrated, frequent observations of the effects on vital signs, filling pressures and resistances are necessary in order to assess the response. As the BP rises with inotropic stimulation, the patient is now ready for very careful attempts at afterload reduction with nitro- prusside. When this therapy is started, have volume (blood if HCT<35, colloid if HCT>35) available, attached to the IV for possible rapid infusion. Often when the patient begins to vasodilate he requires more volume in order to maintain blood pressure.